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Some physicians hope that Belviq will be a safe replacement for fenfluramine, the “fen” in fen-phen. Fen-phen was a combination of the serotonin-booster fenfluramine and the stimulant phentermine. Neither drug produced much weight loss on its own, but combined they were superstars.
There have been numerous allegations over the last fifty years that physicians have directly and indirectly benefited from prescribing phentermine and its various combinations to money conscious patients. However, this is nothing out of the ordinary when it comes to prescription drugs as pharmaceutical companies have time and again been accused of these practices.
“I know that some of you are afraid that the clinicians will combine [Belviq] with phentermine,” Dr. Ed Hendricks, a weight loss physician, and a member of the FDA advisory panel that approved Belviq, told the panel in May. “You have to remember that the motivation behind developing this drug was developing a replacement for fenfluramine that was safe.”
In a study published in the Yonsei Medical Journal, researchers examined the possible link of anorectic drugs to pulmonary hypertension. A 29-year-old woman was admitted to the hospital for shortness of breath and diagnosed with pulmonary hypertension. Researchers unveiled that three months prior to her hospital admittance, she took phentermine for five weeks, which could provide a possible connection between phentermine and pulmonary hypertension. Her symptoms improved with treatment but further research is still needed to closely examine the effects of the drug under different doses.
Phentermine’s staying power has persisted despite F.D.A. approval of four new weight-loss products since 2012, all of which arrived with great fanfare but whose sales have so far failed to live up to expectations.
I’ve been taking ** for 21 days and all it has done is give me a severe bloated stomach. I have lost 4 lbs but it has not curbed my hunger at all. I exercise 4 days a week. Only experienced dry mouth a few days which I guess is good. I have not had the energy boost that others mention. I will finish my 30 day rx but will not waste my money on a refill. It may work for others but not for me and I cannot recommend it.
I was diagnosed with Hashimoto’s Thyroiditis and it makes your metabolism extremely sluggish. I didn’t eat a ton of food but could never lose weight. I was stuck. My endo prescribed this 15mg for me on 12-7-15. I have taken it faithfully since and have lost a very healthy 42 pounds which really helped with my recent hip replacement. I am off for the moment because of my surgery but will go back on and finish what I have plus the 1 refill I have left and then I will be off for awhile. I have found it to be a great help. I have not had any of the terrible emotions or side effects described in some of these reviews. I cut way down on carbs and almost totally eliminated sweets. I really love this medication. My husband saw my success and took the 37.5 prescribed by his MD. He was only allowed for 3 months. He has lost 36 pounds and he has kept up being active. This has been a great boost for each of us. I am so sorry for others problems.
Mekontso-Dessap A, Brouri F, Pascal O, Lechat P, Hanoun N, Lanfumey L, Seif I, Benhaiem-Sigaux N, Kirsch M, Hamon M, Adnot S, Eddahibi S: Deficiency of the 5-hydroxytryptamine transporter gene leads to cardiac fibrosis and valvulopathy in mice. Circulation. 2006 Jan 3;113(1):81-9. Epub 2005 Dec 27. [PubMed:16380550]
This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.
Phentermine has some similarity in its pharmacodynamics with its parent compound, amphetamine, as they both are TAAR1 agonists,[6] where the activation of TAAR1 in monoamine neurons facilitates the efflux or, release into the synapse, of these neurochemicals; at clinically relevant doses, phentermine primarily acts as a releasing agent of norepinephrine in neurons, although, to a lesser extent, it releases dopamine and serotonin into synapses as well.[5][7] Phentermine may also trigger the release of monoamines from VMAT2, which is a common pharmacodynamic effect among substituted amphetamines. The primary mechanism of phentermine’s action in treating obesity is the reduction of hunger perception, which is a cognitive process mediated primarily through several nuclei within the hypothalamus (in particular, the lateral hypothalamic nucleus, arcuate nucleus, and ventromedial nucleus). Outside the brain, phentermine releases norepinephrine and epinephrine – also known as noradrenaline and adrenaline respectively – causing fat cells to break down stored fat as well.
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This includes coronary artery disease, any problems associated with heart rhythm, congestive heart failure, and strokes. You will also want to avoid Phentermine if you have abnormally high blood pressure, an overactive thyroid, have experienced signs of pulmonary hypertension in the past, or if you have abused drugs or alcohol in the past.
Do not use phentermine in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. It is unknown if phentermine is excreted in milk; use of phentermine is contraindicated while breastfeeding.
This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: uncontrolled high blood pressure, glaucoma, personal or family history of a substance use disorder (such as overuse of or addiction to drugs/alcohol), vascular heart disease (e.g., chest pain, heart attack), mental/mood problems (e.g., severe anxiety, bipolar disorder, psychosis, schizophrenia), high blood pressure in the lungs (pulmonary hypertension), stroke, overactive thyroid (hyperthyroidism).
However, by purchasing at least one month’s supply you should start to see some fairly rapid weight loss as long as you stick to the recommended dosage. So please always read the literature and label when you have received your supply of Phentermine.
A: Phentermine is used in conjunction with diet and exercise to lose weight. Side effects associated with phentermine are dry mouth, nervousness, agitation, and trouble sleeping, and it could increase anxiety. Lorazepam and phentermine together are probably not cause for concern, but the use of phentermine and Wellbutrin can increase risk of seizures. Your physician would have to determine the potential risk versus the benefit of taking the two medications together. As for weight loss, studies have shown that eating five small meals a day can help increase the metabolism and maintain constant glucose levels in the body, reducing the feeling of starvation or extreme hunger. Kimberly Hotz, PharmD

In order to maximize the weight loss potential of your phentermine prescription, you should always follow the instructions given to you by your phentermine doctor. Still, sometimes it can be confusing if things weren’t made clear when you picked up your prescription and you’re left thinking, “When should I take my phentermine?”. Here, we’ll explain […]
Q: My doctor prescribed diet pills when I have high blood pressure and Grave’s disease. One day I stopped breathing and they had to do CPR and use the paddles on me. At the hospital, they told my family that my heart was healthy, and that it was most likely the diet pills that the doctor had prescribed to me (phentermine). Do I have any recourse that I can take? Even if it was just to pay all my hospital bills, I had to have a pacemaker put in and can’t drive for 6 months.
Phentermine is similar to amphetamine and may share some of the interactions associated with amphetamines. Combining phentermine with tricyclic antidepressants (for example, amitriptyline [Elavil, Endep]) or monoamine oxidase inhibitors or MAOIs (for example, phenelzine [Nardil], selegiline [Zelapar, Emsam, and Eldepryl], tranylcypromine [Parnate]) may result in high blood pressure and other serious reactions because of elevated serotonin levels in the blood. Phentermine should not be used within 14 days after stopping a monoamine oxidase inhibitor.
You will only want to take Phentermine for a short period of time. The most common dosage is designed to last for a few weeks. At the same time, you do not want to suddenly stop taking Phentermine. Because it is a stimulant, you could experience some rather unpleasant symptoms of withdrawal if you just stop taking it cold turkey. You will want to talk to your doctor to learn how to safely stop taking Phentermine. Make sure that you store Phentermine at room temperature and that you keep it away from any sources of moisture or heat. You will also want to keep track of the amount of medicine that you consume from each bottle. Phentermine is often abused and you want to be mindful if anyone else in your household or office is trying to take it improperly, either with or without a prescription.
A: Phentermine is a prescription medication that is used for short-term weight loss. It is chemically related to amphetamines and works by suppressing the appetite and could have an effect on metabolism. The prescribing information on phentermine does not specifically list nosebleeds as a side effect of the medication. However, this medication may cause an increase in blood pressure that could possibly lead to nosebleeds. The most common side effects of phentermine include: insomnia, hyperactivity, dizziness, dry mouth, unpleasant taste, diarrhea/constipation, mood changes, and restlessness. If you are experiencing nosebleeds and believe that the medication may be causing this side effect you should consult with your physician to be sure that your blood pressure is not elevated. The physician will do a physical exam to see if any underlying conditions may be the cause of your nosebleed and offer suggestions for alleviating this symptom. Lori Poulin, PharmD
Phentermine oral disintegrating tablet (ODT) reaches peak concentrations (Cmax) 3—4.4 hours post-administration. Water ingestion prior to swallowing the ODT did not affect the AUC. Despite a decrease in the Cmax (approximately 5%) and AUC (approximately 12%) when phentermine ODT was administered after a high fat/high calorie breakfast, phentermine ODT can be administered with or without food. The Cmax and AUC were decreased by approximately 7% and 8%, respectively, when the ODT was swallowed without prior disintegration.1
1, 3, 7 – Trimethylxanthine or Caffeine – Is responsible for suppressing appetite. Your body then uses the existing fat to produce energy. At the same time, you don’t feel hungry all the time and you don’t eat as much as you used to.
Pregnancy: Phentermine products are now classified as FDA pregnancy risk category X, as are many anorexiants used for weight loss, and are contraindicated during pregnancy.66   Safe use of phentermine during pregnancy has not been established; there is no known indication for use of phentermine during pregnancy. Phentermine should not be taken by pregnant women or by women who may become pregnant unless, in the opinion of the physician, the potential benefits outweigh the possible hazards.6 
Cayenne pepper – The main ingredients is capsaicin. It comes in a strong concentration, enabling active ingredients to flow smoothly through your body. Simultaneously, it raises the temperature of the body, increasing calorie burning rates, in a process called thermogenesis. Essentially, as temperature increases, the body needs additional energy to dissolve fat.
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